Related Experiment Video
Updated: Sep 30, 2025
05:31
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
340
Gender differences in the dissection properties of ascending thoracic aortic aneurysms
Jianhua Tong1, Mieradilijiang Abudupataer2, Xiaojuan Xu3
1Institute for Biomedical Engineering and Nano Science, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Interactive Cardiovascular and Thoracic Surgery
|March 14, 2022
Summary
Elderly female ascending thoracic aortic aneurysms (ATAA) exhibit lower dissection strength than males, indicating a higher risk for aortic dissection (AD) in older women. Age significantly impacts female ATAA strength, but not male ATAA strength.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Gerontology
Background:
- Ascending thoracic aortic aneurysm (ATAA) presentation, management, and outcomes vary by gender and age.
- Aortic dissection (AD) is a critical complication of ATAA.
Purpose of the Study:
- To investigate the distinct dissection properties of male and female ATAAs.
- To correlate ATAA dissection strength with patient age and gender.
Main Methods:
- Quantitative peeling tests on 41 fresh ATAA samples (22 male, 19 female) from young (≤65 years) and elderly (>65 years) patients.
- Correlation analysis of delamination strength with patient age for both genders.
- Histological examination to characterize dissected morphology.
Main Results:
- Elderly females showed significantly lower circumferential and longitudinal delamination strengths compared to elderly males.
- No significant gender-based differences in delamination strength were observed in younger patients.
- Delamination strength in females significantly decreased with age, a correlation not found in males.
- Histological analysis revealed rougher dissected surfaces in male ATAAs compared to females.
Conclusions:
- Elderly females have a higher propensity for AD compared to age-matched males.
- Surgeons must consider the increased risk of AD in elderly females.
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