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Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

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Published on: August 7, 2014

Plasma Proteomics Analysis of Early Biomarkers for Predicting Female Fecundability: A Nested Case-Control Study.

Lingling Huang¹, Xiang Hong¹, Xuening Zhang^2,3,4

¹Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.

Journal of Proteome Research

|July 31, 2024

Summary

High pyruvate levels in plasma may indicate increased female fecundability, suggesting it as a potential biomarker for fertility. This finding could aid in predicting conception success rates.

Keywords:

fecundability female plasma proteins prediction proteomics pyruvate

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Area of Science:

Reproductive biology
Biochemistry
Clinical diagnostics

Background:

Female fecundability is crucial for reproductive success.
Identifying reliable biomarkers for fecundability is essential for reproductive health.
Current methods for assessing fecundability have limitations.

Purpose of the Study:

To identify and validate novel plasma protein markers for predicting female fecundability.
To investigate the association between specific metabolites and conception rates.

Main Methods:

Nested case-control study design.
Proteomics for biomarker discovery, followed by Western blotting, ELISA, and biochemical tests for validation.
Receiver operating characteristic (ROC) curve analysis and Cox proportional hazard regression were employed.

Main Results:

Pyruvate, a glycolysis product, was significantly elevated in women with high fecundability.
ROC analysis showed an area under the curve of 0.68 for pyruvate, indicating predictive value.
A linear positive association was observed between pyruvate levels and fecundability.

Conclusions:

Pyruvate shows promise as a non-invasive biomarker for predicting female fecundability.
Elevated pyruvate levels correlate with a higher likelihood of conception.
Further research can explore pyruvate's role in reproductive health assessments.