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Complete genome sequence of an Indian outbreak strain of chikungunya virus

Eshna Laha1,2, Deepak Jena1, Viplov K Biswas1,3

  • 1Institute of Life Sciences, Bhubaneswar, India.

Microbiology Resource Announcements
|July 31, 2024
PubMed

Insights

Researchers sequenced the complete genome of an Indian chikungunya virus strain from a 2005-2006 outbreak. This provides crucial data on the virus

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • Chikungunya virus (CHIKV) causes febrile illness with significant morbidity.
  • Large-scale outbreaks of chikungunya have occurred in India, necessitating genomic surveillance.
  • Understanding viral genetic makeup is key to tracking spread and evolution.

Purpose of the Study:

  • To determine the complete genome sequence of a specific Indian strain of chikungunya virus.
  • To provide genomic data from the 2005-2006 chikungunya outbreak in India.

Main Methods:

  • Isolation of chikungunya virus from an infected patient.
  • Whole-genome sequencing of the isolated viral strain.
  • Bioinformatic analysis of the resulting genome sequence.

Main Results:

  • The complete genome sequence of an Indian chikungunya virus strain was determined.
  • The genome length was identified as 11,811 nucleotides.
  • A poly(A) tail of 29 residues was found at the 3' end of the genome.

Conclusions:

  • This study reports the first complete genome sequence of an Indian chikungunya virus strain from the 2005-2006 outbreak.
  • The genomic data contributes to the understanding of chikungunya virus diversity in India.
  • This sequence data can serve as a reference for future epidemiological and evolutionary studies.
Keywords:
CHIKVchikungunya viruswhole genome sequence

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