Deterioration in renal function in patients with chronic renal failure after treatment with captopril

Acute reversible renal failure has been reported in patients receiving captopril, especially those with unilateral or bilateral renal artery stenosis. Two patients with advanced renal disease presented with an acute deterioration in renal function after the introduction of captopril treatment. In both instances this deterioration was irreversible. Captopril should be used with caution in patients with advanced renal disease.