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Prolactinomas: Preconception and During Pregnancy
Catherine D Zhang1, Adriana G Ioachimescu2
1Department of Medicine, Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, HUB for Collaborative Medicine, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Abstract:
Prolactinomas are a common cause of infertility in women. Medical treatment with dopamine agonists (DAs) has an excellent efficacy at restoring fertility and a reassuring safety profile in early pregnancy. Surgical treatment before conception is required in some cases of large macroadenomas and incomplete treatment response. In women with microprolactinomas, the pregnancy course is usually uneventful. In women with macroprolactinomas that are near/abut the optic chiasm, symptomatic tumor enlargement can occur during pregnancy and require a multidisciplinary team approach. This review provides an update regarding outcomes and management of prolactinomas before conception, during pregnancy, and postpartum.
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