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Bioadhesive Polymeric Films Containing Rhamnolipids, An Innovative Antimicrobial Topical Formulation.

Jéssica B Carra1, Kamila B B Wessel2, Giovana N Pereira3

  • 1Departamento de Química, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, PR-445, Km 380 - Campus Universitário, Londrina, Paraná, 86057-970, Brazil.

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Summary
This summary is machine-generated.

New bioadhesive polymeric films containing rhamnolipids show promise for treating acne. These films effectively combat Cutibacterium acnes bacteria, offering a potential alternative to antibiotics.

Keywords:
Cutibacterium acnesbiosurfactantmechanical propertiestopical formulation

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Area of Science:

  • Dermatology
  • Microbiology
  • Materials Science

Background:

  • Acne vulgaris affects a significant portion of the global population, impacting self-esteem.
  • Cutibacterium acnes bacterial overgrowth is a primary factor in acne development.
  • Current topical antibiotic treatments risk antibiotic resistance.

Purpose of the Study:

  • To develop and evaluate bioadhesive polymeric films incorporating rhamnolipids for topical acne treatment.
  • To assess the antimicrobial efficacy of rhamnolipid-loaded films against Cutibacterium acnes.
  • To characterize the physicochemical and mechanical properties of the developed films.

Main Methods:

  • Formulation of four bioadhesive polymeric films with varying rhamnolipid concentrations (0.0-0.3%).
  • Comprehensive characterization including physical, mechanical, and bioadhesive properties.
  • In vitro assessment of antimicrobial activity against Cutibacterium acnes.

Main Results:

  • Films exhibited homogeneous appearance, suitable mechanical properties, skin-like pH, and bioadhesion.
  • Rhamnolipid-loaded films demonstrated significant in vitro antimicrobial activity against C. acnes.
  • The film with 0.3% rhamnolipid concentration showed the highest antimicrobial efficacy.

Conclusions:

  • Bioadhesive polymeric films loaded with rhamnolipids are a viable alternative for acne treatment.
  • Rhamnolipids show potent antimicrobial activity against C. acnes at safe concentrations.
  • The developed film formulation holds potential for effective topical acne therapy.