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Published on: May 10, 2024
Incisional Negative Pressure Wound Therapy for Wounds in Patients with Lower Intestinal Perforations
Yuhei Tsukazaki1, Hiroya Enomoto1, Nana Takeuchi1
1Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan.
Objectives:
Laparotomy for lower intestinal perforation is associated with a high incidence of surgical site infections. This study aimed to assess whether incisional negative pressure wound therapy (iNPWT) could reduce the incidence of these infections and wound dehiscence in patients with lower intestinal perforation.
Methods:
This single-center prospective study was conducted between September 2019 and July 2022. In the therapy group, wounds were closed with subcuticular sutures, and iNPWT was applied at -120 mmHg for 5 days. A total of 10 days of iNPWT was employed. These patients were compared with a historical control group. The iNPWT group (Group A) comprised 22 patients.The historical control group (Group B) had 65 patients. Table outlines patient characteristics and compares the two study groups.
Results:
Patient characteristics were demographically similar. The incidence of surgical site infections was lower in the therapy group than in the control group (9.1% vs. 52.3%, p < 0.001). Wound dehiscence was not observed in the therapy group but was noted in three patients (4.6%) in the control group. In univariate and multivariate analysis, an application of the therapy device was associated with reduced incidence of surgical site infections (p < 0.001 and p = 0.002, respectively).
Conclusions:
The application of iNPWT in patients with lower intestinal perforation was associated with reduced surgical site infections.
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