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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Imaging in Amyloidosis: 20 Years of Sustained Innovation

Marianna Fontana1, Aldostefano Porcari2

  • 1National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, United Kingdom.

JACC. Cardiovascular Imaging
|August 2, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
T1 mappingcardiac magnetic resonanceextracellular volumeglobal longitudinal strainlight-chain (AL) amyloidosismyocardial characterization

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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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