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Advances in Neuroimaging Biomarkers and Scoring
Michelle Machie1, Linda S de Vries2, Terrie Inder3
1Division of Pediatric Neurology, Department of Pediatrics, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA.
Clinics in Perinatology
|August 2, 2024
Summary
Brain MRI is vital for diagnosing and managing neonatal encephalopathy (NE), especially when caused by hypoxic-ischemic encephalopathy (HIE). Advanced MRI scoring systems now aid in understanding NE injury patterns and treatment effectiveness.
Area of Science:
- Neuroimaging
- Neonatal Medicine
- Neurology
Background:
- Neonatal encephalopathy (NE) is a serious condition affecting newborns.
- Hypoxic-ischemic encephalopathy (HIE) is the most common cause of NE.
- Brain MRI is crucial for diagnosing, evaluating, and managing NE.
Purpose of the Study:
- To highlight the role of MRI in understanding NE.
- To discuss the evolution of MRI in HIE.
- To introduce advanced MRI scoring systems.
Main Methods:
- Review of MRI findings in NE and HIE.
- Analysis of historical and current MRI patterns of injury.
- Discussion of the impact of therapeutic hypothermia on MRI assessment.
Main Results:
- MRI provides insights into the biology, nature, and timing of NE.
- Historically, HIE showed basal ganglia/thalamus or watershed injury patterns.
- Advancements in MRI technology and scoring systems have improved NE evaluation.
Conclusions:
- MRI is indispensable for NE diagnosis and management.
- Evolving MRI techniques enhance the understanding of HIE.
- Advanced MRI scoring systems are critical for assessing NE outcomes.
