Associations of Blood Cadmium Levels With Osteoarthritis Among US Adults in NHANES 2013-2018
Lijun Li1, Jiangang Cao, Lin Li
1From the Second Affiliated Hospital, Department of Pharmacy, Hengyang Medical School, University of South China, Hengyang, Hunan, China (Lijun L., Lin L., G.W., J.X.); The Second Affiliated Hospital, Hunan Provincial Key Clinical Laboratory of Basic and Clinical Pharmacological Research of Gastrointestinal cancer, Hengyang Medical School, University of South China, Hengyang, Hunan, China (L.L.); and The Affiliated Nanhua Hospital, Clinical Pharmacy Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China (J.C.).
Background:
Osteoarthritis (OA) is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA.
Method:
Weighted multivariable logistic regression model, trend test, restricted cubic spline, and stratified analysis were used to study the association between BCd and OA.
Results:
In the two regression models of weighted multivariable logistic regression analysis, the correlation between BCd and OA was positive. Compared with the lowest quartile of BCd exposure, the highest quartile had a 2.03-fold (95% confidence interval, 1.67 to 2.47), displaying a dose-response relationship (P for trend <0.00001). The restrictive cubic spline shows a positive linear relationship between BCd and OA.
Conclusion:
There was a positive linear relationship between BCd and OA and a dose-response relationship.
