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Manometric Abnormalities in Patients With and Without Chronic Cough.
WayAnne Watson1, Ethan Simmons2, Adebimpe Adebowale2
1Department of Otolaryngology - Head and Neck Surgery, Loma Linda University Health, United States.
American Journal of Otolaryngology
|August 5, 2024
Summary
Chronic cough may be linked to subtle upper esophageal sphincter (UES) dysfunction, potentially involving vagal hypersensitivity. Further manometry studies are recommended to explore this connection.
Area of Science:
- Gastroenterology
- Otolaryngology
- Neurology
Background:
- Chronic cough (CC) is a common condition with multifactorial causes.
- Vagal hypersensitivity is a proposed mechanism in some CC cases.
- Esophageal motility, particularly upper esophageal sphincter (UES) function, is under-investigated in CC.
Purpose of the Study:
- To investigate the relationship between chronic cough and baseline esophageal motility.
- To assess upper esophageal sphincter (UES) function in patients with and without chronic cough using high-resolution manometry.
Main Methods:
- Retrospective analysis of patients undergoing dysphagia workup.
- Categorization into chronic cough (CC) or control groups based on symptoms.
- High-resolution esophageal manometry to evaluate UES motility parameters.
Main Results:
- 62.5% of the cohort presented with chronic cough.
- No significant demographic differences between cough and control groups.
- Significantly longer UES relaxation duration in the chronic cough group (734 ms vs. 582 ms, p=0.03).
- Laryngopharyngeal reflux (LPR) was a significant predictor of chronic cough (OR 74.04, p=0.010).
Conclusions:
- Subtle alterations in UES function may be present in patients with chronic cough.
- Findings suggest a potential role for vagal hypersensitivity in chronic cough.
- Further manometric studies are warranted to explore UES dysfunction and chronic cough link.
Keywords:
Chronic coughEsophageal motilityHigh-resolution manometry (HRM)Upper esophageal sphincterUpper esophageal sphincter functionVagal hypersensitivityMore Related Videos
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