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Related Experiment Videos

[Diffusion of cefotiam into ascitic fluid].

C Dao, B Hercelin, Y Chotard

    Pathologie-Biologie
    |June 1, 1985
    PubMed
    Summary

    Cefotiam effectively penetrates ascitic fluid, reaching high concentrations within two hours. These levels appear sufficient for treating infections in patients with ascites.

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    Area of Science:

    • Pharmacokinetics
    • Infectious Diseases
    • Internal Medicine

    Context:

    • The large apparent volume of distribution of cefotiam suggests extensive tissue penetration.
    • Ascites, characterized by abnormal fluid accumulation, presents a unique challenge for antibiotic efficacy.
    • Understanding drug concentrations in ascitic fluid is crucial for optimizing treatment of infections in this compartment.

    Purpose:

    • To investigate the diffusion and concentration of cefotiam in ascitic fluid.
    • To determine the pharmacokinetic profile of cefotiam in patients with non-infected ascites.
    • To assess the potential of cefotiam for treating infected ascites based on achieved concentrations.

    Summary:

    • Eight patients with non-infected ascites received a 2g intravenous bolus of cefotiam.
    • Blood and ascitic fluid samples were collected over 24 hours to measure cefotiam concentrations via HPLC.
    • Peak ascitic fluid concentrations averaged 18 µg/ml at 2 hours, remaining elevated at 13 µg/ml by 8 hours.

    Impact:

    • Cefotiam demonstrates significant penetration into ascitic fluid.
    • Achieved cefotiam concentrations in ascites are likely adequate to combat common causative pathogens.
    • This study supports the potential utility of cefotiam in managing infected ascites.

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