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Updated: Jun 17, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Crosstalk between circular RNAs and the STAT3 signaling pathway in human cancer

Mansour Almouh1, Chadi Soukkarieh2, Morshed Kassouha3

  • 1Department of Animal Production, Faculty of Veterinary Medicine, Hama University, Hama, Syria.

Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms
|August 9, 2024
PubMed

Insights

Circular RNAs (circRNAs) regulate the STAT3 signaling pathway in cancer. This review explores how circRNAs impact cancer progression and chemotherapy sensitivity via STAT3, offering new therapeutic insights.

Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Biology

Background:

  • Circular RNAs (circRNAs) are RNA molecules formed by the circularization of pre-mRNA.
  • The STAT3 signaling pathway is crucial in human cancer development and progression.
  • Dysregulated circRNAs expression is observed in various cancers, influencing their roles as tumor suppressors or oncogenes.

Purpose of the Study:

  • To comprehensively review the molecular mechanisms of circRNA regulation of STAT3 signaling in cancer.
  • To explore the crosstalk between STAT3 signaling-related circRNAs and other cancer-related pathways.
  • To discuss the potential of the circRNA/STAT3 axis in cancer chemotherapy.

Main Methods:

  • Literature review of existing studies on circRNAs, STAT3 signaling, and cancer.
  • Analysis of molecular mechanisms linking circRNAs to STAT3 pathway modulation.
  • Synthesis of data on the role of circRNAs in cancer progression and treatment response.

Main Results:

  • CircRNAs can act as tumor suppressors or oncogenes by modulating STAT3 signaling.
  • Specific circRNAs interact with STAT3, influencing gene expression and cellular functions in cancer.
  • The circRNA/STAT3 axis is implicated in resistance and sensitivity to cancer chemotherapy.

Conclusions:

  • Understanding the circRNA-STAT3 interaction provides novel insights into cancer biology.
  • Targeting the circRNA/STAT3 axis may offer new therapeutic strategies for cancer treatment.
  • Further research into circRNAs' role in STAT3-driven malignancies is warranted.
Keywords:
CancerCell signalingCircular RNAsSTAT3microRNAs

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