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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
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Acute Respiratory Failure-II01:21

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Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
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A 36-Year-Old Woman With Intermittent Cyanosis.

Brandon W Moritz1, Fouad Chouairi2, Adam Tosh2

  • 1Department of Internal Medicine, Duke University School of Medicine, Durham, NC; Department of Pediatrics, Duke University School of Medicine, Durham, NC.

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|August 9, 2024
PubMed
Summary
This summary is machine-generated.

A patient developed cyanosis due to phenazopyridine toxicity. This case highlights the importance of considering medication side effects in patients with opioid use disorder presenting with hypoxia.

Area of Science:

  • Toxicology
  • Pharmacology
  • Internal Medicine

Background:

  • Opioid use disorder (OUD) is a chronic relapsing disease.
  • Frequent urinary tract infections (UTIs) are common in women with OUD.

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  • Phenazopyridine is a urinary tract analgesic that can cause methemoglobinemia.