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Updated: Jun 17, 2025
09:15
Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
Published on: April 11, 2025
421
Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review
Jiann-Jy Chen1,2, Chih-Wei Hsu3, Yen-Wen Chen1
1Prospect Clinic for Otorhinolaryngology & Neurology, Kaohsiung 81166, Taiwan.
Diagnostics (Basel, Switzerland)
|August 10, 2024
Summary
Systemic lupus erythematosus (SLE) can cause underdiagnosed audiovestibular dysfunction. Early recognition and steroid treatment may reverse hearing and balance issues in SLE patients.
Area of Science:
- Otolaryngology
- Rheumatology
- Neuroscience
Background:
- Audiovestibular dysfunction in systemic lupus erythematosus (SLE) is often underestimated.
- SLE can impact both auditory and vestibular systems, with proposed mechanisms including immune responses and medication ototoxicity.
Purpose of the Study:
- To systematically review evidence on audiovestibular dysfunction in SLE patients.
- To propose a steroid treatment protocol for managing SLE-related audiovestibular dysfunction.
Main Methods:
- Systematic literature search of PubMed, Embase, ClinicalKey, Web of Science, and ScienceDirect.
- Quality assessment of included articles using the Newcastle-Ottawa Scale.
Main Results:
- Current diagnostic tests for SLE-related audiovestibular dysfunction lack specificity and sensitivity.
- Evidence on treatment efficacy is limited, with no established consensus.
Conclusions:
- Audiovestibular dysfunction in SLE may be reversible with timely diagnosis and adequate treatment.
- A modified steroid treatment protocol is proposed as a potential management strategy.
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