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Effect of Prunus cerasus (Sour Cherry) on Nephrolithiasis in Children: The First Noninferiority Two-Arm Randomized

Fatemeh Ghane-Sharbaf1, Zahra Reza-Jafar2, Elham Bakhtiari3

  • 1Department of Pediatrics, Mashhad University of Medical Sciences Faculty of Medicine, Mashhad, Iran.

Urology Research & Practice
|August 11, 2024
PubMed

Insights

Sour cherry (Prunus cerasus) concentrate effectively reduced kidney stones in children. This study found it comparable to Polycitra-K in treating nephrolithiasis.

Area of Science:

  • Pediatric Nephrology
  • Natural Product Therapeutics
  • Urolithiasis Research

Background:

  • Nephrolithiasis, or kidney stones, is a significant health concern in children.
  • Current treatments for pediatric nephrolithiasis include medical and surgical interventions.
  • Exploring natural remedies like Prunus cerasus offers a potential alternative or complementary approach.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of Prunus cerasus (sour cherry) concentrate in treating nephrolithiasis in children.
  • To compare the effects of sour cherry concentrate with Polycitra-K, a standard medical treatment.

Main Methods:

  • A randomized noninferiority controlled trial was conducted.
  • Children with nephrolithiasis received either sour cherry concentrate or Polycitra-K daily for two months.
  • Kidney stone number and size were assessed using ultrasonography before and after the intervention.

Main Results:

  • Both sour cherry concentrate and Polycitra-K groups showed a significant decrease in kidney stone numbers.
  • No statistically significant difference was observed in the number or percentage of change in calculi between the two groups (P >.05).
  • Urine calcium levels were similar, but uric acid levels were significantly higher in the sour cherry group (P=.012).

Conclusions:

  • Prunus cerasus (sour cherry) demonstrates comparable efficacy to Polycitra-K in managing pediatric nephrolithiasis.
  • Further randomized controlled trials are warranted to validate these findings and explore optimal usage.
  • Sour cherry may offer a viable natural option for children's kidney stone treatment.
Abstract

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