A quick access to CF3-containing functionalized benzofuranyl, benzothiophene and indolyl heterocycles under
Ayazoddin Aunoddin Kazi1,2, Nadimpalli Manjuladevi1, Salla Suresh Kumar1,2
1Fluoro-Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India. lrsingh@iict.res.in.
Abstract:
A catalyst-free one-pot synthetic protocol is presented for the preparation of CF3-containing benzofuran, indolin, and benzothiophene derivatives using readily available aromatic aldehydes and ketones. 2-Bromo-3,3,3-trifluoropropene was employed as a non-corrosive and environmentally benign trifluoromethylacetylene synthon for incorporation of the CF3 group. The reaction proceeds via the formation of a suitably substituted 4,4,4-trifluoro-1-phenylbut-2-yn-1-ol intermediate, which undergoes 5-exo-dig cyclization, resulting in an exocyclic double bond with Z-configuration. The synthetic utility, substrate scope, tolerance to broader substrates are also presented.
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