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Published on: May 25, 2012
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Peri-implant bone changes after using platelet-rich fibrin scaffold among Indians
Abhishek Balani1, Jaishree Tandon1, Vinay Kharsan1
1Department of Oral and Maxillofacial Surgery, New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India.
Bioinformation
|August 12, 2024
Summary
Adding herbal extracts like Moringa oleifera and simvastatin to platelet-rich fibrin scaffolds significantly reduces bone loss around dental implants compared to using scaffolds alone.
Area of Science:
- Dental implantology
- Biomaterials science
- Regenerative medicine
Background:
- Bone regeneration around dental implants is crucial for long-term success.
- Platelet-rich fibrin (PRF) scaffolds are used to enhance bone healing.
- Osteopromotive agents, including herbal extracts, show potential in bone tissue engineering.
Purpose of the Study:
- To compare the efficacy of PRF scaffolds alone versus PRF scaffolds combined with simvastatin (SIM) or Moringa oleifera (MO) in reducing crestal bone loss around dental implants.
- To evaluate the osteopromotive potential of herbal extracts in conjunction with PRF.
- To assess the impact of these combinations on bone regeneration in a clinical setting.
Main Methods:
- A clinical study involving 36 patients and 36 dental implants, divided into three groups (12 implants per group).
- Group 1: PRF scaffolds alone.
- Group 2: PRF scaffolds with simvastatin.
- Group 3: PRF scaffolds with Moringa oleifera.
- Crestal bone alterations were measured using cone-beam computed tomography (CBCT).
Main Results:
- A decrease in crestal bone loss was observed in the PRF + SIM and PRF + MO groups compared to the PRF alone group.
- Both simvastatin and Moringa oleifera, when combined with PRF, demonstrated a beneficial effect on preserving bone around implants.
- CBCT analysis confirmed the reduced bone resorption in the treatment groups.
Conclusions:
- Combining PRF scaffolds with osteopromotive agents like simvastatin and Moringa oleifera is effective in minimizing bone loss around dental implants.
- Herbal osteopromotive agents show promise as adjuncts to PRF in dental implantology.
- These findings support the use of natural and synthetic osteopromotive agents to improve outcomes in bone regeneration around dental implants.
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