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Titin Cardiomyopathy Associated With Refractory Ventricular Tachycardia: A Case Report
Aleksan Khachatryan1, Justin Brilliant2, Ashot Batikyan3
1Department of Internal Medicine, University of Maryland Medical Center, Midtown Campus, Baltimore, USA.
Cureus
|August 13, 2024
Summary
Genetic testing revealed titin gene truncating variants (TTNtv) as the cause of dilated cardiomyopathy (DCM) in a patient with refractory ventricular tachycardias (VTs). This case suggests a link between titin cardiomyopathy and difficult-to-treat VTs, potentially originating from the epicardium.
Area of Science:
- Cardiology
- Genetics
- Internal Medicine
Background:
- Cardiomyopathy encompasses myocardial abnormalities not caused by common cardiac conditions.
- Dilated cardiomyopathy (DCM) frequently involves genetic mutations, particularly titin gene truncating variants (TTNtv).
- TTNtv is implicated in various DCM subtypes, including alcohol, chemotherapy, and peripartum-induced forms.
Keywords:
danicamtivdilated cardiomyopathy (dcm)left ventricular outflow tract obstruction (lvoto)nonischemic cardiomyopathypremature ventricular contractionsright ventricular outflow tracttitintitin genetitin gene truncating variantsventricular tachycardiaMore Related Videos
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