Successfully Nonsurgical Epidermoid Cyst Management with Recombinant Hydrolytic Enzymes: A Case Report

Area of Science:

• Dermatology
• Minimally Invasive Procedures
• Biochemistry

Background:

• Epidermoid cysts (E.C.s), or sebaceous cysts, are common benign subepidermal nodules.
• Traditional management involves surgical excision, carrying risks of complications.
• An alternative minimally invasive approach is explored for E.C. treatment.

Observation:

• A 44-year-old female presented with a decade-old right cheek mass.
• Ultrasound confirmed an E.C. measuring 9.3×6.6 × 9.3 mm.
• The cyst was treated with intralesional recombinant hydrolytic enzymes.

Findings:

• Complete resolution of the E.C. was observed 40 days post-intervention.
• Significant clinical improvement noted by Day 21.
• No recurrence of the E.C. was documented during a 4-year follow-up period.

Implications:

• Intralesional hydrolytic enzyme injection offers a promising alternative for E.C. management.
• This minimally invasive technique may reduce surgical risks and recovery time.
• Further controlled studies are needed to validate efficacy and safety.