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Treatment of foreign body granulomas with combined enzyme therapy
Desirée Giselle Castelanich1, Delfina Pascuzzi2, Jorge López Berroa3
1Private practice, Buenos Aires, Argentina.
Introduction:
Granulomas are focal aggregates of inflammatory cells that form in response to a persistent inflammatory stimulus. Available therapies include surgical and nonsurgical management, and current evidence is based on case series or case reports.
Methods:
Two case reports of foreign body granulomas treated with a combination of recombinant enzymes (hyaluronidase, collagenase, and lipase of bacterial origin) are presented.
Results:
Following three sessions of combined enzyme treatment with a scheduled protocol, both patients showed clinical improvement without any reported adverse events.
Conclusions:
Combined enzyme therapy is an effective, safe, minimally invasive, innovative approach for the treatment of foreign body granulomas.
