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Published on: April 22, 2016
Radical Alkynylthiolation with Visible-Light-Sensitive S-Alkynylthio Sulfonates
Yaonan Xue1, Qirui Dong1, Jiarui Chen1
1College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China.
Abstract:
A novel kind of S-alkynylthio sulfonate, which can be directly activated under visible-light irradiation, has been developed for the radical addition of multiple bond systems and radical coupling with diazonium salts under photocatalyst-free conditions. This strategy features a broad substrate scope, high regioselectivity, excellent tolerance of functional groups, and the late-stage modification of drugs. Experimental and theoretical mechanistic investigations gave reasonable insight into the photolysis of S-alkynylthio sulfonates and C-S bond formation.
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