[Cellulitis. Study of microangiopathy in 254 cases]

Area of Science:

• Endocrinology
• Dermatology
• Pathology

Context:

• Cellulitis, a lipodystrophy, is characterized by microangiopathy, specifically PAS-positive microangiopathy.
• Previous histological and histochemical studies highlighted the significance of this microangiopathy in cellulitis.

Purpose:

• To complement prior research by investigating the relationship between cellulitis, microangiopathy, and diabetes mellitus in a cohort of 254 female patients.
• To analyze the influence of family history of diabetes and glucose tolerance test results on patients with cellulitis and confirmed microangiopathy.

Summary:

• A cohort of 254 female patients with cellulitis and biopsy-confirmed dermohypodermic capillary microangiopathy was studied.
• Patients were stratified into four groups based on family history of diabetes mellitus and response to a cortisone-sensitized glucose overload test (Fajans-Conn test).
• Results were analyzed to explore the etiopathogenesis of both diabetes and microangiopathy, considering potential generic and/or immunological links.

Impact:

• Provides insights into the complex interplay between cellulitis, microangiopathy, and metabolic factors like diabetes.
• Contributes to understanding the potential shared etiopathogenesis of these conditions.
• Highlights the importance of microangiopathy in the context of cellulitis and its potential association with glucose metabolism disorders.