Rapid Access to Triarylmethanes (TRAMs) Enabled by Direct Electrolysis of Indolizines with Carbonyls
Pooja Kumari Jat1, Satpal Singh Badsara1
1MFOS Laboratory, Department of Chemistry, University of Rajasthan, JLN Marg, Jaipur, Rajasthan 302004, India.
Abstract:
A fast, scalable, transition metal-free, electrochemical sp2 geminal functionalization of carbonyls enabled by anodic oxidation of non-prefunctionalized chromone-fused indolizines to access the triarylmethanes (TRAMs) is disclosed for the first time. This momentary electrochemical approach features the use of readily available carbonyls, implantation of the C(sp3) center (well-known for dramatically improving biological active potency), a broad substrate scope, and excellent yields of TRAMs with fluorescence properties.
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