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Related Experiment Videos

Glucose tolerance during chronic propranolol treatment.

M D Cressman, D G Vidt, H Mohler

    Journal of Clinical Hypertension
    |June 1, 1985
    PubMed
    Summary

    Propranolol, a beta-blocker, may worsen glucose tolerance in hypertensive patients. Some patients experienced increased fasting glucose and hyperglycemia, suggesting a potential side effect of this blood pressure medication.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Pharmacology

    Background:

    • Chronic diuretic therapy in hypertensive patients can impair glucose tolerance.
    • Beta-blocker monotherapy is known to affect glucose tolerance in diabetic patients.
    • Limited data exists on chronic beta-blocker effects in non-diabetic hypertensive individuals.

    Purpose of the Study:

    • To prospectively evaluate the impact of propranolol monotherapy on glucose tolerance in hypertensive patients without diabetes.
    • To assess changes in fasting and postload glucose levels during long-term propranolol treatment.

    Main Methods:

    • A prospective study involving 13 non-diabetic hypertensive patients.
    • Treatment with propranolol monotherapy.
    • Monitoring of glucose tolerance over 18 months, including fasting glucose and 2-hour postglucose-load plasma glucose measurements.

    Main Results:

    • One patient developed diabetes mellitus within the first month of treatment.
    • After one year, 4 out of 11 patients showed a ≥30% increase in fasting glucose.
    • After 18 months, 9 patients exhibited significantly increased fasting and 2-hour postglucose-load plasma glucose levels.

    Conclusions:

    • Chronic propranolol monotherapy may lead to hyperglycemia in hypertensive patients.
    • The observed changes in glucose metabolism, while of questionable biologic significance, indicate a potential side effect of beta-blocker therapy.
    • Close monitoring for hyperglycemia is advised in hypertensive patients on beta blockers.

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