Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
Neural Regulation01:37

Neural Regulation

39.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.2K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

JAMA·2026
Same author

Does lifestyle intervention lower clinically significant cognitive impairment risk?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Cognitive Control in Pediatric Cancer Survivors: A task-fMRI study.

bioRxiv : the preprint server for biology·2026
Same author

Evaluating early vs. late static SUVR windows of [¹⁸F]MK-6240 tau PET in Alzheimer disease: a head-to-head comparison study.

European journal of nuclear medicine and molecular imaging·2026
Same author

More Publications Needed on Cognitively Impaired-Not MCI: Call for Papers.

Alzheimer disease and associated disorders·2026
Same author

Poor R-wave progression associates with cerebral amyloid deposition: A potential link between heart and brain.

Journal of Alzheimer's disease : JAD·2026

Related Experiment Video

Updated: Jun 16, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.3K

Increased between-network connectivity: A risk factor for tau elevation and disease progression.

Seyed Hani Hojjati1, Tracy A Butler1, José A Luchsinger2

  • 1Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, United States.

Neuroscience Letters
|August 17, 2024
PubMed
Summary

Increased between-network connectivity in the brain may predict future Alzheimer's disease (AD) progression. This finding suggests a key mechanism for tau tangle spread and offers insights into early AD pathogenesis.

Keywords:
Alzheimer’s diseaseBetween-network connectivityPositron emission tomography (PET)Preclinical stagesResting-state functional magnetic resonance imaging (rs-fMRI)Tau

More Related Videos

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.3K
Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

8.9K

Related Experiment Videos

Last Updated: Jun 16, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.3K
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.3K
Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

8.9K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Gerontology

Background:

  • Neurofibrillary tau tangles are a hallmark of Alzheimer's disease (AD).
  • Tau pathology typically begins in the medial temporal lobe (MTL), but spread mechanisms are unclear.
  • Brain connectivity patterns shift with aging and preclinical AD, with increased between-network connectivity observed.

Purpose of the Study:

  • To investigate the role of increased between-network connectivity in facilitating tau spread in early Alzheimer's disease.
  • To identify individuals at risk for future tau elevation and AD progression using connectivity patterns.

Main Methods:

  • Longitudinal study of 46 healthy elderly participants over 2-3 years.
  • Utilized resting-state functional MRI (rs-fMRI), structural MRI, and 18F-MK6240 PET tau tracer.
  • Employed unsupervised agglomerative clustering to analyze connectivity and tau deposition.

Main Results:

  • Individuals with increased between-network connectivity showed higher future tau deposition and entorhinal cortex thinning.
  • Higher between-network connectivity correlated with lower delayed scores on the Selective Reminding Test (SRT).
  • In the limbic network, increased between-network connectivity strongly associated with tau progression, particularly in beta-amyloid positive individuals.

Conclusions:

  • Increased between-network connectivity is a predictor of future tau deposition and Alzheimer's disease progression.
  • This finding supports the hypothesis that altered brain connectivity plays a critical role in AD pathogenesis.
  • The study enhances understanding of AD development in preclinical stages.