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Do quinolones really augment the antifungal effect of amphotericin B in vitro?

B P Overbeek, M Rozenberg-Arska, J Verhoef

Drugs Under Experimental and Clinical Research

|January 1, 1985

Abstract:

The minimum inhibitory concentrations (MICs) for amphotericin B and the quinolones norfloxacin and ciprofloxacin against 30 clinical isolates of Candida albicans were determined in various liquid media. Interaction studies were carried out to investigate a possible synergistic action of the quinolones on the antifungal effect of amphotericin B. No interaction between the drugs studied was observed in any of the media used.

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