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Swept-source optical coherence tomography in ocular surface diseases: anterior segment analysis repeatability and its
Alberto Recchioni1,2,3, Abinaya Priya Venkataraman4, Saaeha Rauz1,2
1Academic Unit of Ophthalmology, Institute of Inflammation and Aging, University of Birmingham, Birmingham, United Kingdom.
Frontiers in Medicine
|August 19, 2024
Summary
Anterior segment optical coherence tomography (AS-OCT) shows reliable repeatability for measuring ocular parameters in various ocular surface disorder (OSD) groups. This technology is promising for assessing OSD, even with dry eye challenges.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Ocular surface disorders (OSD) can impact the accuracy of anterior segment measurements.
- Assessing repeatability of anterior segment optical coherence tomography (AS-OCT) in diverse OSD cohorts is crucial for clinical application.
Purpose of the Study:
- To evaluate the repeatability of AS-OCT for various anterior segment parameters in different ocular surface disorder (OSD) cohorts.
- To determine the accuracy of AS-OCT measurements in distinct disease groups.
Main Methods:
- Utilized the Tomey CASIA 2 device for nonmydriatic AS-OCT imaging in 239 participants across six OSD groups and healthy controls.
- Assessed parameters including anterior chamber depth, width, angle metrics, corneal thickness, keratometry, and lens vault.
- Performed statistical analyses to determine repeatability limits and coefficients of variation (CoV) within each cohort.
Main Results:
- AS-OCT demonstrated consistent repeatability for anterior chamber and corneal parameters across all OSD groups.
- The trabecular iris-space area showed a coefficient of variation (CoV) of approximately 20% in all cohorts.
- Anterior chamber depth measurements varied in immune (CoV = 2.5%) and non-immune (CoV = 3.8%) OSD groups, while width and angle-to-angle measurements were similar across groups. Keratometry remained stable (CoV < 1%).
Conclusions:
- The Tomey CASIA 2 device offers reliable repeatability for anterior segment parameter measurement in diverse OSD populations.
- Despite dry eye challenges, AS-OCT shows potential for OSD assessment, possibly enabling clinical protocols similar to those for healthy individuals.
