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Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Allergic Reactions02:06

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Background and Environment Affect Phenotype02:27

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Related Experiment Video

Updated: Jun 16, 2025

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Environmental Influences on Atopic Eczema.

Wismmy Lee1, Fihr Chaudhary1, Devendra K Agrawal1

  • 1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.

Journal of Environmental Science and Public Health
|August 19, 2024
PubMed
Summary

Environmental factors significantly influence atopic eczema (also known as atopic dermatitis). Understanding these environmental triggers is key to developing preventative strategies for this common skin condition.

Keywords:
Air pollutantsAllergensAtopic dermatitisAtopic eczemaAtopyClimate changeEnvironmentHome environmentMicrobiomeNeurodermatitisNutritional factorsStructural racism

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Area of Science:

  • Dermatology
  • Environmental Health
  • Epidemiology

Background:

  • Atopic eczema (atopic dermatitis) is a chronic skin condition with increasing prevalence globally, especially in industrialized nations.
  • Its incidence suggests environmental factors play a larger role than genetics.
  • Environmental variables significantly impact the initiation and severity of atopic eczema.

Purpose of the Study:

  • To comprehensively analyze the role of environmental factors in the pathogenesis of atopic eczema.
  • To enhance understanding of atopic dermatitis disease patterns.
  • To identify potential preventative measures for atopic eczema.

Main Methods:

  • Review of existing literature on environmental influences and atopic eczema.
  • Analysis of epidemiological data on atopic dermatitis prevalence.
  • Synthesis of research on environmental triggers and disease mechanisms.

Main Results:

  • Environmental factors are strongly implicated in the rising incidence of atopic eczema.
  • Specific environmental exposures contribute to the development and exacerbation of atopic dermatitis.
  • The study highlights the complex interplay between environment and genetic predisposition.

Conclusions:

  • Environmental modifications may offer viable strategies for preventing and managing atopic eczema.
  • Further research into specific environmental determinants is crucial for targeted interventions.
  • Understanding environmental pathogenesis is essential for public health approaches to atopic dermatitis.