Related Experiment Video
Updated: Jun 16, 2025
06:47
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
9.6K
Environmental Influences on Atopic Eczema.
Wismmy Lee1, Fihr Chaudhary1, Devendra K Agrawal1
1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Journal of Environmental Science and Public Health
|August 19, 2024
Summary
Environmental factors significantly influence atopic eczema (also known as atopic dermatitis). Understanding these environmental triggers is key to developing preventative strategies for this common skin condition.
Area of Science:
- Dermatology
- Environmental Health
- Epidemiology
Background:
- Atopic eczema (atopic dermatitis) is a chronic skin condition with increasing prevalence globally, especially in industrialized nations.
- Its incidence suggests environmental factors play a larger role than genetics.
- Environmental variables significantly impact the initiation and severity of atopic eczema.
Purpose of the Study:
- To comprehensively analyze the role of environmental factors in the pathogenesis of atopic eczema.
- To enhance understanding of atopic dermatitis disease patterns.
- To identify potential preventative measures for atopic eczema.
Main Methods:
- Review of existing literature on environmental influences and atopic eczema.
- Analysis of epidemiological data on atopic dermatitis prevalence.
- Synthesis of research on environmental triggers and disease mechanisms.
Main Results:
- Environmental factors are strongly implicated in the rising incidence of atopic eczema.
- Specific environmental exposures contribute to the development and exacerbation of atopic dermatitis.
- The study highlights the complex interplay between environment and genetic predisposition.
Conclusions:
- Environmental modifications may offer viable strategies for preventing and managing atopic eczema.
- Further research into specific environmental determinants is crucial for targeted interventions.
- Understanding environmental pathogenesis is essential for public health approaches to atopic dermatitis.
Related Concept Videos
01:20Gene-Environment Interactions
270
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
270
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:20Asthma: Pathogenesis and Management
376
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
376
02:06Allergic Reactions
27.3K
Overview
27.3K
02:27Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K