Related Experiment Videos
Microencapsulation and controlled release of insulin from polylactic acid microcapsules
Biomaterials, Medical Devices, and Artificial Organs
|January 1, 1985
Summary
This study optimized insulin microcapsule production using polylactic acid and ethylcellulose. Polyvinyl alcohol at 3% concentration yielded the best results for sustained insulin release.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Biomedical Engineering
Background:
- Insulin delivery requires effective encapsulation for controlled release.
- Biodegradable and non-biodegradable polymers offer distinct advantages for microcapsule formulation.
- Protective colloids play a crucial role in microencapsulation process outcomes.
Purpose of the Study:
- To investigate the impact of protective colloids on insulin microcapsule properties.
- To optimize the formulation for sustained insulin release.
- To compare polylactic acid and ethylcellulose microcapsules.
Main Methods:
- Emulsification-solvent evaporation technique for microencapsulation.
- Utilized gelatin and polyvinyl alcohol as protective colloids.
- Analyzed micromeritic properties and in vitro release profiles.
Main Results:
- Higher protective colloid concentrations reduced microcapsule particle size.
- Increased viscosity of protective colloids led to smaller median diameters.
- Polyvinyl alcohol resulted in nonporous microcapsules, enhancing controlled release compared to gelatin.
Conclusions:
- Protective colloid type and concentration significantly influence insulin microcapsule characteristics.
- 3% polyvinyl alcohol is optimal for polylactic acid microcapsules, achieving prolonged insulin release.
- Microcapsule surface morphology impacts drug release kinetics, enabling sustained delivery.