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Interrogating Explicit Solvent Effects on the Mechanism and Site-Selectivity of Aryl Halide Oxidative Addition to

Jingru Lu1, Holly Celuszak1, Irina Paci1

  • 1Department of Chemistry, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5 C2, Canada.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 19, 2024
PubMed
Summary

Solvent polarity and basicity significantly influence palladium-catalyzed oxidative addition rates and selectivity. Hydrogen bonding impacts reactivity, while polar solvents favor specific mechanisms for electron-deficient pyridines and triflates.

Keywords:
OrganopalladiumOxidative additionRegioselectivitySolvent effectscross-coupling

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