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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Photoactivable malachite green-based alkynylplatinum(II) 2,6-bis(N-alkylbenzimidazol-2-yl)pyridine complexes
Andy Shun-Hoi Cheung1, Ming-Yi Leung1, Tony Ho-Ching Fung1
1Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. wwyam@hku.hk.
Abstract:
Photo-responsive malachite green moieties have been incorporated into an alkynylplatinum(II) bzimpy system. The photo-caged complexes in acetonitrile solutions exhibit self-assembly properties modulable by photo-removal of the cyano protecting group. Distinct aggregate morphologies, which are facilitated by the non-covalent metal-metal and π-π stacking interactions, have been observed before and after photo-irradiation.
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