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Related Experiment Video

Updated: May 5, 2026

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

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Self-Assembled BODIPY@Au Core-Shell Structures for Durable Neuroprotective Phototherapy.

Melody Cai-Syaun Wu¹, Jack Hau-Ting Wei¹, Ricky Yu-Syun Fan¹

¹Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan R.O.C.

Chembiochem : a European Journal of Chemical Biology

|August 22, 2024

Summary

New BODIPY-based nanoagents improve phototherapy by enhancing singlet oxygen production and reducing dark toxicity. These nanophotosensitizers also show promise for neuroprotection by suppressing tau aggregation.

Keywords:

BODIPY Gold nanoparticles Photosensitizers Singlet oxygen Tau protein

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Area of Science:

Nanotechnology
Photochemistry
Neuroscience

Background:

BODIPY analogs are potential photosensitizers but suffer from high dark toxicity and low singlet oxygen generation.
Developing effective photosensitizers for phototherapy requires overcoming these limitations.

Purpose of the Study:

To design and characterize novel self-assembled core-shell nanophotosensitizers based on BODIPY.
To enhance photostability and singlet oxygen production efficiency.
To investigate the neuroprotective potential of these nanophotosensitizers.

Main Methods:

Synthesis of Bpy-BODIPY and its self-assembly on gold nanourchins.
Characterization using UV-visible spectroscopy, TEM, SERS, and DLS.
Assessment of tau protein aggregation suppression and neuroprotective effects.

Main Results:

Successful formation of core-shell nanophotosensitizers with J-aggregates.
Enhanced photostability and singlet oxygen generation capacity.
Significant suppression of tau protein aggregation and enhanced neuroprotection.

Conclusions:

The developed Bpy-BODIPY@Au nanophotosensitizers overcome limitations of traditional BODIPY analogs.
These nanoagents offer improved phototherapy capabilities and demonstrate neuroprotective potential.
This study expands BODIPY chemistry applications into nanoagents for neurodegenerative disease therapy.