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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
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Current and future therapies for follicular lymphoma
Pier Luigi Zinzani1, Javier Muñoz2, Judith Trotman3
1IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia Seràgnoli, Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy.
Experimental Hematology & Oncology
|August 22, 2024
Summary
Follicular lymphoma (FL) treatment has improved survival, but it remains incurable. This review covers current and emerging therapies for relapsed or refractory FL, focusing on patient needs and treatment risks.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Follicular lymphoma (FL) is an indolent B cell neoplasm with improved survival due to recent treatments.
- Despite advances, FL remains heterogeneous, incurable, and characterized by relapses.
- Some patients face early progression, transformation, or treatment toxicity, highlighting unmet needs.
Purpose of the Study:
- To review the current treatment landscape for relapsed or refractory FL.
- To discuss promising novel therapies in development for FL.
- To provide a real-world perspective on unmet needs and individualized treatment approaches.
Main Methods:
- Literature review of current and emerging treatments for relapsed/refractory FL.
- Analysis of efficacy, risks, and patient-centered considerations.
- Exploration of novel therapeutic strategies.
Main Results:
- Current treatments offer improved survival but do not provide a cure for FL.
- Emerging therapies present diverse options for relapsed or refractory disease.
- Individualized treatment selection requires balancing risks, benefits, and patient preferences.
Conclusions:
- Novel therapies are expanding options for relapsed/refractory FL.
- A nuanced, patient-specific approach is crucial for optimal management.
- Addressing unmet needs in FL requires careful consideration of treatment risks and benefits.
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