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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....

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Related Experiment Video

Updated: Jun 15, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Emerging methods and applications in 3D genomics.

Simona Pedrotti¹, Ilaria Castiglioni¹, Cynthia Perez-Estrada²

¹Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.

Current Opinion in Cell Biology

|August 23, 2024

Summary

This summary is machine-generated.

3D genomics technologies have rapidly advanced since Hi-C’s inception, offering higher resolution and single-cell analysis. This review covers new tools and applications in genome organization, projecting future directions.

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Last Updated: Jun 15, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

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Published on: January 25, 2020

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

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Published on: February 28, 2021

Area of Science:

Genomics
Molecular Biology
Biotechnology

Background:

The field of 3D genomics has rapidly evolved since the development of Hi-C in 2009.
Numerous high-throughput sequencing methods now exist to map the three-dimensional (3D) genome organization in eukaryotic cells.

Purpose of the Study:

To review the latest advancements in 3D genomic technologies.
To highlight recent developments and applications in the past three years.
To provide an outlook on the future of this technology-driven field.

Main Methods:

Review of high-throughput sequencing methods for 3D genome profiling.
Summary of single-cell Hi-C variations.
Inclusion of novel chromatin organization tools beyond proximity ligation.

Main Results:

Significant increases in genomic resolution achieved by current methods.
Development of single-cell versions of Hi-C.
Emergence of new tools for higher-order chromatin organization analysis.

Conclusions:

The 3D genomics landscape is expanding with innovative technologies.
Recent years have seen substantial progress in resolution and application scope.
The field is poised for further technological innovation and discovery in genome organization.