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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

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Published on: August 22, 2016

Gingerol-zinc complex loaded 3D-printed calcium phosphate for controlled release application.

Vishal Sharad Chaudhari¹, Bryson White¹, Aditi Dahiya¹

¹W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.

Drug Delivery and Translational Research

|August 23, 2024

Summary

A novel gingerol-zinc complex (G-Zn+2) integrated into 3D-printed calcium phosphate scaffolds enhances bone regeneration and combats bacterial infections, showing significant potential for bone disorder treatment.

Keywords:

3D printing Bone scaffold Calcium phosphate Gingerol Zinc metal complex

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Published on: August 8, 2022

Area of Science:

Biomaterials Science
Nanotechnology
Orthopedics

Background:

Natural medicines show promise for bone disorders, with gingerol from ginger roots exhibiting osteogenic properties.
Zinc (Zn) is crucial for bone health and possesses antibacterial capabilities.
Complexing gingerol with zinc (G-Zn+2) may enhance therapeutic efficacy for bone regeneration.

Purpose of the Study:

To investigate the potential of a 3D-printed calcium phosphate (CaP) scaffold loaded with a gingerol-zinc (G-Zn+2) complex for bone regeneration.
To evaluate the drug release kinetics, cellular interactions, and antibacterial properties of the G-Zn+2 loaded scaffold.
To assess the scaffold's efficacy in promoting osteoblast activity and inhibiting bacterial growth.

Main Methods:

Fabrication of a porous 3D-printed CaP scaffold.
Coating the scaffold with polycaprolactone (PCL) to control drug release.
Loading the scaffold with the G-Zn+2 complex and studying its release kinetics.
Evaluating cytotoxicity against MG-63 osteosarcoma cells.
Assessing osteoblast cell viability, alkaline phosphatase activity, and antibacterial efficacy against Staphylococcus aureus.

Main Results:

The G-Zn+2 complex exhibited cytotoxicity towards osteosarcoma cells.
The PCL-coated scaffolds demonstrated controlled release of the G-Zn+2 complex over 6 weeks.
Scaffolds loaded with G-Zn+2 significantly increased osteoblast viability and alkaline phosphatase activity.
The G-Zn+2 complex showed significant antibacterial activity against Staphylococcus aureus.

Conclusions:

The G-Zn+2 complex holds potential for bone regeneration and infection prevention.
Functionalized 3D-printed CaP scaffolds offer a promising approach for treating bone disorders.
This innovative scaffold system warrants further investigation for low-load-bearing applications.