Quality-of-Life Outcomes Following Endoscopic Resection of Sinonasal Inverted Papilloma

Area of Science:

• Otolaryngology
• Surgical Oncology
• Quality of Life Research

Background:

• Sinonasal tumors, including inverted papilloma (IP), impact patient quality of life (QOL).
• Assessing postoperative QOL is crucial for understanding treatment outcomes in IP patients.

Purpose of the Study:

• To investigate the natural history of postoperative QOL in patients treated for sinonasal inverted papilloma.
• To identify factors influencing long-term QOL following surgical resection of IP.

Main Methods:

• Retrospective review of 373 patients with sinonasal IP treated at 4 academic rhinology centers.
• Sino-Nasal Outcome Test-22 (SNOT-22) scores were collected preoperatively and at 1, 3, 6, and 12 months postoperatively.
• Repeated-measures ANOVA and linear regression analyses were used to assess QOL changes and influencing factors.

Main Results:

• Mean SNOT-22 scores significantly decreased from preoperative levels (20.6) to 3 months postoperatively (11.8) (p < 0.001).
• Improvements were noted in nasal, sleep, and otologic/facial domains, but not the emotional domain.
• Recurrent IP was associated with significantly higher long-term SNOT-22 scores (β=7.08, p=0.017).

Conclusions:

• Surgical treatment for IP leads to significant QOL improvements by 3 months postoperatively, primarily in nasal, sleep, and otologic/facial functions.
• Recurrence of IP is a significant predictor of poorer long-term QOL outcomes.
• The emotional QOL subdomain did not show significant improvement post-surgery.