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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
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A spotlight on the aged pulmonary artery.
Dalma Horvat1, Lucia Agoston-Coldea2
12nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Advances in Clinical Chemistry
|August 24, 2024
Summary
Aging significantly impacts the pulmonary artery (PA), affecting cardiovascular health. New non-invasive methods like cardiac magnetic resonance (CMR) show promise for assessing PA aging and guiding clinical decisions.
Area of Science:
- Cardiovascular Medicine
- Gerontology
- Vascular Biology
Background:
- Global life expectancy is increasing, highlighting aging as a significant cardiovascular risk factor.
- Aging affects the pulmonary artery (PA) through endothelial dysfunction, inflammation, and structural changes, impacting pulmonary hemodynamics.
- Pulmonary artery atherosclerosis is an understudied aspect of vascular aging.
Purpose of the Study:
- To review the mechanisms of aging-induced pulmonary artery alterations.
- To explore current and emerging techniques for assessing pulmonary artery aging and hemodynamics.
- To emphasize the need for comprehensive assessments in an aging population.
Main Methods:
- Review of existing literature on aging, pulmonary arteries, and cardiovascular risk factors.
- Discussion of diagnostic modalities including right heart catheterization (RHC), echocardiography, and cardiac magnetic resonance (CMR) imaging.
- Analysis of mechanisms like endothelial dysfunction, inflammation, and structural remodeling.
Main Results:
- Aging leads to significant changes in PA structure and function, affecting hemodynamics.
- Right heart catheterization (RHC) is the gold standard for hemodynamic evaluation but carries risks.
- Echocardiography is useful for screening pulmonary hypertension (PH), while CMR shows promise for non-invasive assessment of PA stiffness and hemodynamics.
Conclusions:
- Pulmonary artery aging is a critical factor in cardiovascular health for the elderly.
- Non-invasive imaging techniques like CMR offer advanced capabilities for assessing PA aging.
- Comprehensive evaluation strategies are essential for managing cardiovascular health in an aging global population.
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