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Transparent and Conformal Microcoil Arrays for Spatially Selective Neuronal Activation.

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|August 26, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microcoil array for precise neuronal activation using micromagnetic stimulation (microMS). This technology shows promise for brain-machine interfaces and prosthetic vision.

Keywords:
Micromagnetic stimulationactivating functionactivationbioelectronicscortexneural prothesisneuronretina

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Micromagnetic stimulation (microMS) offers high spatial resolution for neuronal activation.
  • Current microMS technologies face challenges in precise targeting and biocompatibility.

Purpose of the Study:

  • To develop and validate a microcoil array for localized activation of cortical neurons and retinal ganglion cells.
  • To establish a computational model for optimizing microcoil design for targeted neural stimulation.

Main Methods:

  • Designed and fabricated a flexible, transparent SU-8/Cu/SU-8 tri-layer microcoil array with four individually-addressable microcoils.
  • Developed a computational model to predict the electric field gradient and activation region.
  • Tested the device on mouse cortex and retina explants expressing GCaMP6.

Main Results:

  • Achieved localized neuronal activation with an anisotropic region of activation <50 microm wide.
  • Demonstrated repeated, dose-dependent activation of individual neurons within 40 microm of microcoil tips.
  • Confirmed the device's flexibility, transparency, and conformal properties.

Conclusions:

  • The developed microcoil array enables precise, localized neural activation via microMS.
  • This technology holds significant potential for advancing brain-machine interfaces and bioelectronic therapies, including prosthetic vision.