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DNA-Engineered Degradable Invisibility Cloaking for Tumor-Targeting Nanoparticles.

Yan Zhao^1,2, Junjun Hou³, Linjie Guo¹

¹Institute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.

Journal of the American Chemical Society

|August 28, 2024

Summary

This summary is machine-generated.

Scientists developed DNA-engineered invisibility cloaking (DEIC) to prevent nanoparticle sequestration by the liver. This novel approach enhances targeted delivery of nanoagents to tumors in vivo.

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Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

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Area of Science:

Biomedical Engineering
Nanotechnology
Drug Delivery

Background:

Nanoparticle (NP) delivery systems are crucial for cancer therapy and vaccines.
Liver sequestration of NPs significantly hinders targeted delivery efficiency.
Overcoming liver phagocytosis is essential for effective in vivo nanoagent delivery.

Purpose of the Study:

To develop a DNA-engineered strategy to circumvent liver phagocytosis.
To enhance tumor-targeted delivery of nanoagents using a novel cloaking method.
To investigate the potential of DNA-engineered invisibility cloaking (DEIC) for theranostic applications.

Main Methods:

Coating NPs with a DNA monolayer to adsorb dysopsonin proteins and induce liver invisibility.
Utilizing the tunable degradation of DNA shells in vivo to trigger tumor-specific uptake.
Evaluating DEIC using Ag2S quantum dots and nanoliposomes in mouse models.
Employing near-infrared-II imaging to quantify tumor-to-liver delivery ratios.

Main Results:

The DNA monolayer on NPs preferentially adsorbed serum dysopsonin proteins, rendering them functionally invisible to the liver.
Tumor-specific uptake was achieved through the in vivo degradation of the DNA shell, with tunable degradation rates.
DEIC demonstrated efficacy in both Ag2S quantum dot and nanoliposome systems.
Near-infrared-II imaging showed a high tumor-to-liver ratio of up to ~5.1, an 18-fold improvement over conventional nanomaterials.

Conclusions:

DNA-engineered invisibility cloaking (DEIC) effectively circumvents liver sequestration of NPs.
This approach significantly enhances tumor-targeted delivery of nanoagents in vivo.
DEIC offers a potentially universal strategy for high-efficiency targeted delivery of theranostic agents.