Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.0K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus Guidelines for Staging and Surveillance Imaging in Cutaneous Squamous Cell Carcinoma.

JAMA dermatology·2026
Same author

How We Do It: Botulinum Toxin as an Adjunct to Improve Full-Thickness Skin Graft Survival of the Distal Digit.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Development of a Core Outcome Domain Set for Facial Aging.

JAMA dermatology·2026
Same author

Reconstruction of a Large Nasal and Cheek Defect in a Patient With Tobacco Use.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Skin Microbiome Patterns Associated with Basal Cell Carcinoma: A Case Series.

Microorganisms·2026
Same author

The efficacy of tranexamic acid in prevention and treatment of post-inflammatory hyperpigmentation: a pilot study.

Clinical and experimental dermatology·2026

Related Experiment Video

Updated: Jun 15, 2025

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

939

Using Neuromodulators to Improve Scar Formation, Keloids, Rosacea, and Antiaging.

Monica Rosales Santillan1, David Ozog1,2, Woffles Wu3

  • 1Department of Dermatology, Henry Ford Health, Detroit, Michigan.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|August 28, 2024
PubMed
Summary

Botulinum toxin A (BoNT-A) effectively treats scars, rosacea, and aging signs by improving skin appearance. However, more research is needed to understand its long-term effects and optimal retreatment frequency.

More Related Videos

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

6.7K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

820

Related Experiment Videos

Last Updated: Jun 15, 2025

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

939
In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

6.7K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

820

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Medical Research

Background:

  • Botulinum toxin A (BoNT-A) is utilized for various dermatological applications.
  • Its precise mechanisms and long-term impacts on scar formation, rosacea, and antiaging require further investigation.

Purpose of the Study:

  • To review existing literature on BoNT-A for scar formation, rosacea, and antiaging.
  • To explore the toxin's mechanism of action and treatment protocols.

Main Methods:

  • A comprehensive literature search was performed using PubMed.
  • Included studies focused on botulinum toxin treatments for scars, rosacea, and antiaging.
  • Author's clinical experience with BoNT-A for these conditions was also incorporated.

Main Results:

  • The mechanism of action for BoNT-A in scar improvement, rosacea management, and antiaging is increasingly understood.
  • Short-term efficacy is established, but data on long-term effects and optimal retreatment intervals remain limited.

Conclusions:

  • In vitro studies support BoNT-A's mechanism in dermatology.
  • Further clinical research is essential to determine long-term outcomes and refine treatment strategies for scar formation, rosacea, and antiaging.