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Skin autofluorescence and cause-specific mortality in a population-based cohort
Henderikus E Boersma1,2, Andries J Smit2, Andrew D Paterson3,4
1Department of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1HPC AA31 9700 RB, P.O. Box 30001, Groningen, The Netherlands.
Scientific Reports
|August 28, 2024
Summary
The study found that higher levels of SAF (serum adiponectin fasting) were linked to increased cardiovascular and cancer mortality in the general population. These associations remained significant even after adjusting for age, sex, smoking, and BMI.
Area of Science:
- Cardiovascular Disease Epidemiology
- Metabolic Health Research
- Oncology Outcomes
Background:
- Serum adiponectin fasting (SAF) is an adipokine with known associations to metabolic and cardiovascular health.
- Previous research suggests a complex relationship between adiponectin levels and mortality, requiring further investigation in diverse populations.
Purpose of the Study:
- To investigate the association between serum adiponectin fasting (SAF) levels and cardiovascular mortality in a general population sample.
- To explore the relationship between SAF and other disease-specific mortality rates, including cancer mortality.
Main Methods:
- A cohort of 77,143 participants without pre-existing diabetes or cardiovascular disease was evaluated.
- Cox proportional hazard analysis was used to assess associations between SAF and all-cause, cardiovascular, and cancer mortality.
- Data on causes of death were obtained from the municipality database, with a median follow-up of 115 months.
Main Results:
- Higher SAF levels were observed across all mortality groups.
- The highest quartile of SAF was significantly associated with increased cardiovascular mortality (HR 1.8 after age adjustment), though significance was lost with further adjustments.
- A consistent association was found between the highest SAF quartile and increased cancer mortality (HR 1.7 after full adjustments).
Conclusions:
- Serum adiponectin fasting (SAF) is associated with increased all-cause mortality.
- SAF demonstrates a significant association with cardiovascular and cancer-related mortality in the general population.
- These findings highlight the potential prognostic value of SAF in predicting mortality risk.
