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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Papain Suppresses Atopic Skin Inflammation through Anti-Inflammatory Activities Using In Vitro and In Vivo Models.

Hye-Min Kim1,2, Yun-Mi Kang2,3, Minho Lee4

  • 1Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.

Antioxidants (Basel, Switzerland)
|August 29, 2024
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Summary
This summary is machine-generated.

Papain (PN) effectively reduced atopic dermatitis (AD) symptoms in mice by decreasing inflammation and improving skin barrier function. This study shows PN

Keywords:
Dermatophagoides farinae bodyNC/Ngaatopic dermatitiskeratinocytespapain

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Area of Science:

  • Enzymology
  • Dermatology
  • Immunology

Background:

  • Papain (PN), a proteolytic enzyme from Carica Papaya L., has potential pharmacological benefits beyond digestion.
  • Its effects on skin inflammation, particularly in atopic dermatitis (AD), are not well-established.

Purpose of the Study:

  • To investigate the anti-inflammatory effects of PN on house dust mite (Dermatophagoides farinae) body (Dfb)-induced atopic dermatitis (AD) in NC/Nga mice and HaCaT keratinocytes.
  • To elucidate the underlying mechanisms of PN's action in AD pathogenesis.

Main Methods:

  • Histological examination, transepidermal water loss (TEWL) measurement, RT-qPCR, Western blotting, and ELISA were used.
  • Assays were performed on Dfb-exposed AD mice and H2O2-damaged HaCaT keratinocytes.

Main Results:

  • Oral PN intake reduced AD lesion severity, TEWL, epidermal thickness, and mast cell infiltration in mice.
  • PN suppressed inflammatory cytokines, serum IgE, and inhibited MAPK/STAT pathways in both mice and keratinocytes.
  • PN enhanced antioxidant enzyme expression and improved keratinocyte survival against oxidative stress.

Conclusions:

  • Oral administration of Papain (PN) suppresses inflammatory mediators and downregulates the MAPK/STAT pathway.
  • PN demonstrates potential therapeutic effects against atopic dermatitis (AD) pathogenesis.