Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiation biology.

E J Hall

    Cancer
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Radiobiological experiments have historically shaped radiotherapy, leading to current fractionation schedules. Ongoing research explores new techniques like hyperfractionation and hyperthermia for improved cancer treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pharmacokinetics of GS-441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021-2024).

    The Journal of small animal practice·2025
    Same author

    Whole-Blood Taurine Concentrations in Cats With Intestinal Disease.

    Journal of veterinary internal medicine·2017
    Same author

    Comparison of 3 Handling Techniques for Endoscopically Obtained Gastric and Duodenal Biopsy Specimens: A Prospective Study in Dogs and Cats.

    Journal of veterinary internal medicine·2016
    Same author

    Campylobacter Species and Neutrophilic Inflammatory Bowel Disease in Cats.

    Journal of veterinary internal medicine·2016
    Same author

    Bacterial Cholangitis, Cholecystitis, or both in Dogs.

    Journal of veterinary internal medicine·2016
    Same author

    Does the Murphy's eye perform its role?

    Anaesthesia·2015
    Same journal

    Toward exercise as standard care for older cancer survivors.

    Cancer·2026
    Same journal

    Maintenance therapy in gynecologic malignancies: Current and future state.

    Cancer·2026
    Same journal

    Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study.

    Cancer·2026
    Same journal

    Large-scale osteosarcoma sequencing reveals age-associated genomic architectures.

    Cancer·2026
    Same journal

    EZH2 inhibitor tazemetostat voluntarily withdrawn from market.

    Cancer·2026
    Same journal

    Nivolumab and chemotherapy combination approved for previously untreated Hodgkin lymphoma.

    Cancer·2026
    See all related articles

    Area of Science:

    • Radiobiology
    • Radiation Oncology
    • Medical Physics

    Background:

    • Historical radiobiological experiments, such as those in the 1920s demonstrating testicular sterilization through fractionated irradiation, significantly influenced early radiotherapy practices.
    • Post-World War II research utilizing mammalian cell cultures, animal tumor models, and normal tissue systems has generated substantial data, enhancing our understanding of conventional radiotherapy.
    • Current radiotherapy techniques are increasingly understood through fundamental radiobiological principles.

    Purpose of the Study:

    • To review the historical impact of radiobiological experiments on radiotherapy.
    • To explore emerging concepts and future directions in radiation oncology based on experimental data.
    • To highlight the foundational role of radiobiology in advancing cancer treatment modalities.

    Related Experiment Videos

    Main Methods:

    • Historical analysis of seminal radiobiological studies.
    • Review of experimental data from mammalian cell cultures, animal models, and normal tissue studies.
    • Synthesis of established radiobiological principles with current and future radiotherapy techniques.

    Main Results:

    • Early experiments on fractionated irradiation directly informed modern radiotherapy fractionation schedules.
    • Extensive post-WWII research has provided a robust data set for understanding radiotherapy.
    • Established radiobiological principles now underpin conventional radiotherapy techniques.

    Conclusions:

    • Radiobiology has been pivotal in shaping radiotherapy, from historical fractionation to modern applications.
    • Future radiotherapy may involve altered fractionation (hyperfractionation, accelerated treatment), neutron therapy selection, and the use of hyperthermia.
    • Continued integration of radiobiological research is essential for advancing radiation oncology and improving patient outcomes.