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Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Exploring Candidate Gene Studies and Alexithymia: A Systematic Review.

Yazmín Hernández-Díaz¹, Alma Delia Genis-Mendoza², Thelma Beatriz González-Castro¹

¹División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86205, Mexico.

|August 29, 2024

Summary

This review highlights candidate genes linked to alexithymia, particularly those in the serotoninergic pathway and neurotransmitter metabolism. Further research is needed to fully understand the genetic underpinnings of alexithymia.

Keywords:

alexithymia biomarkers genes

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Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Alexithymia is characterized by difficulties in emotional processing.
Genetic factors are implicated in the pathogenesis of alexithymia.
Previous research has explored candidate genes associated with alexithymia.

Purpose of the Study:

To conduct a systematic review of genetic association studies on alexithymia.
To identify candidate genes and genetic variants associated with alexithymia.
To synthesize current knowledge on the genetic background of alexithymia.

Main Methods:

A systematic review of genetic studies was performed.
Searches were conducted in PubMed, Scopus, and Web of Science databases.
Seventeen studies comprising 22,361 individuals met the eligibility criteria.

Main Results:

Candidate gene studies were the primary focus.
Identified genes include those in the serotoninergic pathway (SLC6A4, HTR1A, HTR2A).
Other associated genes involve neurotransmitter metabolism (DRD2, ANKK1, COMT, BDNF, OXTR) and other pathways (VDBP, TP53AIP1, ARHGAP32, TMEM88B).

Conclusions:

The majority of identified genes are involved in serotoninergic pathways and neurotransmitter metabolism.
These findings suggest a role for serotoninergic neurotransmission in alexithymia.
Further research is necessary to elucidate the precise role of these genes in alexithymia.