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The Development of Lung Tissue Engineering: From Biomaterials to Multicellular Systems
Jingge Ma1,2, Chengtie Wu3,4, Jinfu Xu1,2
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, P. R. China.
Advanced Healthcare Materials
|August 29, 2024
Summary
Lung tissue engineering offers solutions for end-stage lung disease by developing advanced constructs for regeneration and study. This review details acellular, monocellular, and multicellular systems, highlighting future directions for functional lung repair.
Area of Science:
- Regenerative Medicine
- Biomedical Engineering
- Pulmonology
Background:
- End-stage lung disease necessitates innovative treatments, driving demand for lung tissue engineering.
- Lung tissue engineering aims to regenerate lung tissue and facilitate respiratory pathology research.
Purpose of the Study:
- To provide an overview of recent advancements in lung tissue engineering.
- To categorize and describe various lung tissue-engineered constructs.
- To discuss challenges and future directions in the field.
Main Methods:
- Review of recent achievements and representative research in lung tissue engineering.
- Categorization of engineered constructs into acellular, monocellular, and multicellular systems.
- Discussion of biomaterials, manufacturing technologies, and cell types used.
Main Results:
- Lung tissue-engineered constructs are categorized into three main systems: acellular, monocellular, and multicellular.
- These systems are applicable to reconstructing various lung components, including the trachea, airway epithelium, alveoli, and whole lungs.
- Key research highlights and advancements in each category are presented.
Conclusions:
- Lung tissue engineering holds promise for functional lung regeneration and permanent lung substitution.
- Further research into biomaterials, manufacturing, and cell integration is crucial for clinical translation.
- This review offers insights for developing effective lung regeneration strategies.
