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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: Jun 14, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Protocol for establishing and evaluating a cancer cachexia mouse model.

Zhijun Zhou¹, Jingxuan Yang¹, Mingyang Liu¹

¹Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

|September 1, 2024

Summary

This summary is machine-generated.

This study details a protocol for creating and assessing cancer cachexia mouse models. These models help researchers study the clinical features of cachexia in patients.

Keywords:

Cancer Cell Biology Cell culture Health Sciences Metabolism Model Organisms Systems biology

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Last Updated: Jun 14, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Published on: July 25, 2020

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Area of Science:

Oncology
Animal Models
Physiology

Background:

Cancer cachexia significantly impacts patient health and quality of life.
There is a critical need for reliable mouse models that accurately reflect human cancer cachexia.
Current models require standardized protocols for consistent evaluation.

Purpose of the Study:

To present a comprehensive protocol for establishing and evaluating cancer cachexia mouse models.
To provide detailed steps for tumor cell preparation, inoculation, and surgical procedures.
To outline key methods for assessing cachexia indicators in established mouse models.

Main Methods:

Detailed surgical procedures for tumor cell inoculation in mice.
Grip strength testing to evaluate muscle function.
Tissue collection and histological analysis for muscle cross-sectional area measurement.

Main Results:

Successful establishment of cancer cachexia mouse models.
Demonstrated efficacy of grip strength tests in assessing muscle wasting.
Quantifiable data on muscle tissue changes through cross-sectional area analysis.

Conclusions:

The presented protocol enables the reliable creation and evaluation of cancer cachexia mouse models.
These models serve as valuable tools for investigating cancer cachexia mechanisms and testing interventions.
Standardized assessment methods ensure reproducibility and comparability across studies.