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Immune function and renal transplantation in Fabry's disease
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
|January 1, 1985
Summary
Patients with Fabry's disease undergoing renal transplantation do not show specific immune deficiencies. Their immune function is comparable to the general uraemic population, suggesting other factors contribute to infection risk.
Area of Science:
- Immunology
- Nephrology
- Transplantation
Background:
- Fabry's disease is associated with a high rate of lethal infections post-renal transplantation.
- A potential cause is a deficient leucocyte immunological function.
Purpose of the Study:
- To investigate the immunological status of patients with Fabry's disease undergoing renal transplantation.
- To determine if specific immune impairments contribute to increased infection rates.
Main Methods:
- Studied humoral immunity.
- Analyzed peripheral lymphocyte subsets.
- Assessed mitogenic lymphocyte response in vitro.
- Evaluated granulocyte function in three Fabry's disease patients.
Main Results:
- Immunological profiles were similar across patients.
- No specific impairment in humoral immunity or lymphocyte subsets was observed.
- Granulocyte function and lymphocyte response to mitogens were not significantly different from uraemic controls.
Conclusions:
- The immunological state in Fabry's disease patients is generally similar to the uraemic population.
- No specific leucocyte immunological deficiency was identified as a cause for high infection rates.
- Other factors likely contribute to the observed high infection rates in these patients.