Do we really need ligands in Ir-catalyzed C-H borylation?

Area of Science:

• Organic Chemistry
• Catalysis
• Synthetic Methodology

Background:

• Direct borylation of C-H bonds is a key strategy for synthesizing complex organic molecules.
• This method is crucial for late-stage functionalization and metabolite synthesis, enabling access to diverse chemical structures.

Purpose of the Study:

• To provide a comprehensive overview and classification of catalytic systems for direct C-H borylation.
• To highlight recent advancements and trends in this rapidly evolving research field.

Main Methods:

• Literature review and classification of existing catalytic systems for direct C-H borylation.
• Utilizing high-throughput experimentation to investigate selectivity in directed-borylation reactions.

Main Results:

• Identification and categorization of various catalytic systems for C-H borylation.
• Discovery of unexpected selectivity differences between two established directed-borylation systems.

Conclusions:

• Direct C-H borylation is a versatile and growing area in synthetic chemistry.
• The study underscores the importance of rigorous control experiments, even with established methods, to ensure reliable catalytic outcomes.